PAN Olsztyn

Demonstration of the presence of PGE2 positive feedback loop in the porcine endometrium at the time of the maternal recognition of pregnancy. Primary conceptus signal, E2, and conceptus-derived PGE2 regulate the expression of prostaglandin synthesis pathway enzymes to favor the production of luteoprotective PGE2 in the endometrium.

Cloning and sequencing of the porcine PGF2alpha synthase and PGE2 synthase cDNAs and characterization of their expression in the endometrium and conceptus/trophoblast;

Determination of vascular endothelial growth factor (VEGF) and its receptors expression in the uterus during the estrous cycle and early pregnancy in pigs, that suggest its important role in implantation process and placenta development;

Discovery of the LH receptors expression in the non-gonadal tissues of the porcine reproductive tract (confirmed later in other animal species and in human) and determination of the LH effect on the endometrium, myometrium and oviduct functions in different physiological states;