- HPLC gradient system with autosampler (LC-20, Shimadzu, Japan) coupled with DAD detector (SPD-M20A, Shimadzu, Japan) and mass spectrometer (QTRAP 5550 AB SCIEX, Shimadzu, Japan).

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HPLC gradient system with autosampler (LC-10, Shimadzu, Japan) coupled with DAD detector (SPD-M10AVP, Shimadzu, Japan) and mass spectrometer (LCMS- QP8000α, Shimadzu, Japan);
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HPLC gradient system with autosampler (LC-10, Shimadzu, Japan) coupled with UV-Vis detector (SPD-10A, Shimadzu, Japan) and fluorescence detector (RF-10AXL, Shimadzu, Japan);
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HPLC gradient system with autosampler (LPG-3400M, WPS-3000TSL, Dionex, USA) coupled with multi-channel electrochemical detector (5600A, ESA, USA) and fluorescence detector (FLD-3400RS, Dionex, USA);
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HPLC isocratic system (LC-10, Shimadzu, Japan) coupled with two electrochemical detectors (ICA-3000, TOA, Japan and ED40, Dionex, USA);
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gas chromatograph (7890A, Agilent, USA) with MS and FID detectors;
- software for pharmacokinetic calculation Biokinetica.
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